LRP1 Antibody - CD BioSciences

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LRP1 Antibody

LRP1 Antibody

SPA-07035

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Target Information
Target Name LRP1
Gene Abbr. LRP1
Gene ID 4035
Full Name LDL receptor related protein 1
Alias A2MR, APOER, APR, CD91, IGFBP-3R
Introduction Low density lipoprotein receptor related protein 1 ( LRP1) is a type I transmembrane receptor that mediates the endocytosis of various ligands. LRP1 plays important roles in lipid homeostasis, signaling transduction, embryonic development, and glucose metabolism. In addition, LRP1 regulates APP processing and facilitates the clearance of beta-amyloid. This finding makes LRP1 a potential therapeutic target for Alzheimer’s disease. LRP1 preprotein is proteolytically processed by furin to generate a 515 kDa extracellular α subunit and a membrane-anchored 85 kDa β subunit, which together form the mature receptor.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of human LRP1 protein.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LRP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 85
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity It recognizes endogenous levels of total LRP1 β subunit.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.