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Latrophilin 3/LPHN3 Antibody
SPA-06914
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Latrophilin 3/LPHN3 |
| Gene Abbr. | ADGRL3 |
| Gene ID | 23284 |
| Full Name | adhesion G protein-coupled receptor L3 |
| Alias | CIRL3, CL3, LEC3, LPHN3 |
| Introduction | LPHN3 (Latrophilin 3; also CIRL3, CL3 and LEC3) is a (presumably) 220 kDa member of the LN-TM7 subfamily, GPCR 2 family of molecules. It appears to have a restricted expression pattern, being limited to brain and adrenal gland. Although it is related to the black widow toxin receptor CIRL1, it does not serve as a toxin receptor. Mature human Latrophilin 3 is a 7-TM glycoprotein that is 1428 amino acids (aa) in length. Post-translational processing cleaves the molecule into a 120 kDa ECD (aa 20-841) and a noncovalently-associated 85 kDa 7-TM C-terminus (aa 842-1447). The ECD is modular and contains a SUEL-like lectin domain (aa 35-124), an Olf region (aa 134-393) and GPS domain (aa 802-853). There are multiple splice events which, in the ECD, include a two aa substitution for aa 127-131, a 13 aa insertion after Lys623, and a 39 aa substitution for aa 668-1447. Over aa 20-832, human Latrophilin 3 shares 98% aa identity with mouse Latrophilin 3. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 801518 |
| Isotype | IgG1 |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human Latrophilin 3/LPHN3. Met1-Arg813. Accession # Q9HAR2. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (2 µg/mL) |
| Reactivity | Human, Mouse, Rat |
| Specificity | Detects human Latrophilin 3/LPHN3 in direct ELISAs and human, mouse, and rat Latrophilin 3/LPHN3 in Western Blots. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.