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Latent TGF-beta bp4 Antibody
SPA-07061
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | LTBP4 |
| Gene Abbr. | LTBP4 |
| Gene ID | 8425 |
| Full Name | latent transforming growth factor beta binding protein 4 |
| Alias | ARCL1C, LTBP-4, LTBP4L, LTBP4S |
| Introduction | LTBP-4 is a 170 kDa extracellular glycoprotein that belongs to the LTBP/fibrillin family. These proteins contain a conserved pattern of eight cysteine residues (8Cys) and EGF-like domains. Mouse LTBP-4 isoform 1 is synthesized as 1666 amino acid residues and contains 14 EGF-like motifs and three 8Cys, the 3rd of which is responsible for disulfide-association with the latency-linked associated peptide (LAP) of latent TGF-beta 1. LTBP-4 is expressed in multiple tissues and is involved in the assembly, secretion and targeting of latent TGF-beta to sites where it can be activated. Two additional splice isoforms that differ from isoform 1 in residues 60‑150 or 67‑150, have been described. Human and mouse LTBP-4 share 90% amino acid sequence homology. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Latent TGF‑ beta bp4 isoform 1. Ser25-Ala1666 (Arg542-Pro547). Accession # AAI41006. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (0.1 µg/mL) |
| Reactivity | Mouse |
| Specificity | Detects mouse Latent TGF‑ beta bp4 in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, less than 1% cross-reactivity with recombinant human (rh) LTBP-1 and rhLTBP-2 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.