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Lamin A/C Antibody
SPA-06873
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Lamin A/C |
| Gene Abbr. | LMNA |
| Gene ID | 4000 |
| Full Name | lamin A/C |
| Alias | CDCD1, CDDC, CMD1A, CMT2B1, EMD2 |
| Introduction | Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear dysregulation and cell death. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 133A2 |
| Immunogen | Recombinant protein specific to the carboxy terminus of human lamin A protein. |
| Source/Purification | Antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human lamin A protein. |
| Usage | |
|---|---|
| Application | WB, IF, IHC |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 74 (A), 63 (C) |
| Reactivity | Human |
| Sensitivity | Endogenous |
| Specificity | It recognizes endogenous levels of total lamin A protein. It also reacts with large fragments of lamin A (50 kDa) produced by caspase cleavage during apoptosis. This antibody does not cross-react with lamin C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.