JNK3 Antibody - CD BioSciences

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JNK3 Antibody

JNK3 Antibody

SPA-06796

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Target Information
Target Name JNK3
Gene Abbr. MAPK10
Gene ID 5602
Full Name mitogen-activated protein kinase 10
Alias JNK3, JNK3A, PRKM10, SAPK1b, p493F12
Introduction The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase. Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs. Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member. There are three SAPK/JNK genes each of which undergoes alternative splicing, resulting in numerous isoforms. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 2B10H12
Isotype IgG2A
Immunogen Purified recombinant fragment of human MAPK10 (AA: 180-329) expressed in E. coli.
Usage
Application WB, ELISA
Dilutions Western Blot (1:500-1:2000); ELISA (1:10000)
MW(KDa) 54
Reactivity Human, Rat
Storage & Handling
Storage Buffer PBS.
Preservative 0.05% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

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