IRAK3/IRAK-M Antibody - CD BioSciences

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IRAK3/IRAK-M Antibody

IRAK3/IRAK-M Antibody

SPA-06522

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name IRAK-M
Gene Abbr. IRAK3
Gene ID 11213
Full Name interleukin 1 receptor associated kinase 3
Alias ASRT5, IRAKM
Introduction Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs. IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases.Unlike IRAK1 and IRAK4, IRAK2 and IRAK-M do not have significant kinase activity although they can still activate NF-κB when overexpressed. Expression of IRAK-M is more restricted compared to other family members with highest levels of expression occurring in monocytes/macrophages. Studies from IRAK-M knockout mice suggest that IRAK-M may play a role as a negative regulator of Toll-like receptor signaling and innate immune responses by preventing the dissociation of IRAK1 and IRAK4 from MyD88 and the subsequent formation of its complex with TRAF6.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant protein of human IRAK3.
Usage
Application WB, IHC
Dilutions Western Blot (1:500-1:2000); Immunohistochemistry (1:50-1:200)
MW(KDa) 68
Reactivity Human, Mouse
Specificity Human IRAK3.
Storage & Handling
Storage Buffer PBS (pH 7.3), 50% Glycerol.
Preservative 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

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