IRAK1 Antibody - CD BioSciences

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IRAK1 Antibody

IRAK1 Antibody

SPA-06525

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Target Information
Target Name IRAK1
Gene Abbr. IRAK1
Gene ID 3654
Full Name interleukin 1 receptor associated kinase 1
Alias IRAK, pelle
Introduction Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs. IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen A peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK. The immunogen is located within the last 50 amino acids of IRAK. Amino Acid Squence: DRQGPEESDEFQS.
Usage
Application WB, ELISA, IF, IP
Dilutions Western Blot (1 µg/mL); ELISA (1:100-1:2000); Immunofluorescence (10-20 µg/mL); Immunoprecipitation (2-4 µg/mL)
MW(KDa) 78-105
Reactivity Human, Mouse, Rat
Specificity At least three isoforms of IRAK1 are known to exist; this antibody will detect all three isoforms. IRAK1 antibody is predicted to not cross-react with other members of the IRAK protein family.
Storage & Handling
Storage Buffer PBS.
Preservative 0.02% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.