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IP3R3 Antibody
SPA-06508
| Size | Price |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IP3 Receptor |
| Gene Abbr. | ITPR3 |
| Gene ID | 3710 |
| Full Name | inositol 1,4,5-trisphosphate receptor type 3 |
| Alias | IP3R, IP3R3 |
| Introduction | Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3R1, 2, and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation. Four individual subunits homo- or hetero-oligomerize to form the receptor's functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may be a mode of regulation for Ca2+ release. IP3R1-mediated Ca2+ release appears to have an effect on the induction of for long-term storage depression (LTD) in Purkinje cells. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | The immunogen recognized by this antibody maps to a region between residue 1755 and 1825 of human inositol 1,4,5-triphosphate receptor, type 3 using the numbering given in entry NP_002215.2 (GeneID 3710). |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:2000-1:10000); Immunoprecipitation (2-5 μg/mg lysate) |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | Tris-Citrate/Phosphate (pH 7.0-8.0). |
| Preservative | 0.09% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
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