IKKα Antibody - CD BioSciences

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IKKα Antibody

IKKα Antibody

SPA-05465

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Target Information
Target Name IKKα
Gene Abbr. CHUK
Gene ID 1147
Full Name component of inhibitor of nuclear factor kappa B kinase complex
Alias IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Introduction The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins. Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB. The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Produced in rabbits immunized with E. coli-derived Human IKK alpha fragment.
Usage
Application IHC
Reactivity Human
Storage & Handling
Storage Buffer PBS (pH 7.0).
Preservative 0.03% Proclin
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.