IKKα Antibody - CD BioSciences

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IKKα Antibody

IKKα Antibody

SPA-05463

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Target Information
Target Name IKKα
Gene Abbr. CHUK
Gene ID 1147
Full Name component of inhibitor of nuclear factor kappa B kinase complex
Alias IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Introduction The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins. Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB. The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 4D11
Isotype IgG1 Kappa
Immunogen CHUK (NP_001269, 646 a.a. ~ 745 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. RQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE.
Usage
Application WB, ELISA, IF
Dilutions Western Blot (1:500)
MW(KDa) 85
Reactivity Human
Specificity CHUK - conserved helix-loop-helix ubiquitous kinase.
Storage & Handling
Storage Buffer In 1X PBS, pH 7.4.
Preservative No Preservative
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.