HSP27 siRNA I - CD BioSciences

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HSP27 siRNA I

HSP27 siRNA I

SPR-00562

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Target Information
Target Name HSP27
Gene Abbr. HSPB1
Gene ID 3315
Full Name heat shock protein family B (small) member 1
Alias CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27
Introduction Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels. In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway. Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers. It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization.
Usage
Application RNA interference
Reactivity
Storage & Handling
Storage Buffer The siRNA product is supplied in RNAse-free water.
Storage Temp. Aliquot and store at -20 °C.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.