HDAC4 Antibody - CD BioSciences

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HDAC4 Antibody

HDAC4 Antibody

SPA-04950

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
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Target Information
Target Name HDAC4
Gene Abbr. HDAC4
Gene ID 9759
Full Name histone deacetylase 4
Alias AHO3, BDMR, HA6116, HD4, HDAC-4
Introduction Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D15C3
Immunogen Recombinant protein specific to the amino terminus of human HDAC4 protein.
Source/Purification Antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human HDAC4 protein.
Usage
Application WB, IP
Dilutions Western Blot (1:2000); Immunoprecipitation (1:100)
MW(KDa) 140
Reactivity Human, Mouse, Rat, Monkey
Sensitivity Endogenous
Specificity It recognizes endogenous levels of total HDAC4 protein. The antibody may cross-react with HDAC5.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.