Gα(z) Antibody - CD BioSciences

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Gα(z) Antibody

Gα(z) Antibody

SPA-04250

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Target Information
Target Name G protein
Gene Abbr. GNAZ
Gene ID 2781
Full Name G protein subunit alpha z
Alias gz-alpha
Introduction Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines, and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities. Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation.Gα(z) stands out from other G proteins because it lacks an ADP-ribosylation consensus site for pertussis toxin, giving it a possible role in signal transduction pathways resistant to the toxin, such as phospholipase C. Gα(z) is phosphorylated and activated by protein kinase C (PKC) at Ser27.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant protein encompassing a sequence within the center region of human GNAZ.
Usage
Application WB
Dilutions Western Blot (1:500-1:3000)
MW(KDa) 40
Reactivity Human, Mouse, Rat, Primate
Storage & Handling
Storage Buffer 0.1 M Tris (pH 7), 0.1 M Glycine, 10% Glycerol.
Preservative 0.01% Thimerosal
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

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