Fer Antibody - CD BioSciences

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Fer Antibody

Fer Antibody

SPA-03851

Size Price
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100 µg Online Inquiry
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Target Information
Target Name Fer
Gene Abbr. FER
Gene ID 2241
Full Name FER tyrosine kinase
Alias PPP1R74, TYK3, p94-Fer
Introduction Fes/Fps and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. Fes and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. Fes/Fps was originally identified as an oncogene from avian (Fps) and feline (Fes) retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. Mutations may activate the Fps kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-Fes protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 690318
Isotype IgG1
Immunogen E. coli-derived recombinant human Fer. Asn93-Ala302. P16591.
Usage
Application IHC
Dilutions Immunohistochemistry (8-25 µg/mL)
Reactivity Human
Specificity Detects human Fer in direct ELISAs.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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