Fer Antibody - CD BioSciences

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Fer Antibody

Fer Antibody

SPA-03849

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Target Information
Target Name Fer
Gene Abbr. FER
Gene ID 2241
Full Name FER tyrosine kinase
Alias PPP1R74, TYK3, p94-Fer
Introduction Fes/Fps and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. Fes and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. Fes/Fps was originally identified as an oncogene from avian (Fps) and feline (Fes) retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. Mutations may activate the Fps kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-Fes protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Synthetic peptide made to an internal portion of human FER (within residues 400-450). [Swiss-Prot# P16591].
Usage
Application WB, IF
Dilutions Western Blot (0.5 µg/mL); Immunofluorescence (1:500)
Reactivity Human, Mouse, Canine
Validation Knockdown Validated.
Storage & Handling
Storage Buffer PBS and 30% Glycerol.
Preservative 0.1% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

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