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ERC1α Antibody
SPA-03646
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ERC1 |
| Gene Abbr. | ERC1 |
| Gene ID | 23085 |
| Full Name | ELKS/RAB6-interacting/CAST family member 1 |
| Alias | Cast2, ELKS, ERC-1, RAB6IP2 |
| Introduction | ERC1, an acronym named for previous protein names ELKS, RAB6IP2 and CAST, is a RIM-binding protein that plays a role in neurotransmitter release and general membrane trafficking in other cell types. Interaction with the GTP-binding protein Rab6 suggests that it contributes to membrane traffic at the Golgi. In addition to its association with membrane trafficking, ERC1 has also been found as an essential part of the IκB kinase (IKK) complex required for the activation of NF-κB, perhaps by recruiting IκBα to the IKK complex. Alternative splicing of ERC1 generates 2 proteins with a divergent carboxy terminus, a long and a short form termed ERC1α and ERC1β, respectively. ERC1α is widely expressed, whereas ERC1β and a related family member ERC2 are expressed in the brain. Papillary thyroid carcinomas have been identified with the translocation t(10;12)(p11;p13) resulting in a fusion between ERC1 and the receptor tyrosine kinase Ret. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Immunogen | Synthetic peptide corresponding to residues at the carboxy terminus of human ERC1 protein, specific for the α isoform. |
| Source/Purification | Antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the carboxy terminus of human ERC1 protein, specific for the α isoform. Antibodies were purified by peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:50) |
| MW(KDa) | 130 |
| Reactivity | Human |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of the α isoform of human ERC1. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. |
| Preservative | No Preservative |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.