ERC1 Antibody - CD BioSciences

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ERC1 Antibody

ERC1 Antibody

SPA-03645

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Target Information
Target Name ERC1
Gene Abbr. ERC1
Gene ID 23085
Full Name ELKS/RAB6-interacting/CAST family member 1
Alias Cast2, ELKS, ERC-1, RAB6IP2
Introduction ERC1, an acronym named for previous protein names ELKS RAB6IP2 and CAST is a RIM-binding protein that plays a role in neurotransmitter release and general membrane trafficking in other cell types. Interaction with the GTP-binding protein Rab6 suggests that it contributes to membrane traffic at the Golgi. In addition to its association with membrane trafficking, ERC1 has also been found as an essential part of the IκB kinase (IKK) complex required for the activation of NF-κB, perhaps by recruiting IκBα to the IKK complex. Alternative splicing of ERC1 generates 2 proteins with a divergent carboxy terminus, a long and a short form termed ERC1α and ERC1β, respectively. ERC1α is widely expressed, whereas ERC1β and a related family member ERC2 are expressed in the brain. Papillary thyroid carcinomas have been identified with the translocation t(10;12)(p11;p13) resulting in a fusion between ERC1 and the receptor tyrosine kinase Ret.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to residues near the amino terminus of ERC1 protein.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of ERC1 protein. Antibodies are purified by peptide affinity chromatography.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:100)
MW(KDa) 130, 120
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity It detects endogenous levels of ERC1 protein. Both α and β isoforms of ERC1 are detected.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.