Endoglin/CD105 Antibody - CD BioSciences

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Endoglin/CD105 Antibody

Endoglin/CD105 Antibody

SPA-03403

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Target Information
Target Name Endoglin/CD105
Gene Abbr. ENG
Gene ID 2022
Full Name endoglin
Alias END, HHT1, ORW1
Introduction CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Product Details
Host Goat
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Mouse myeloma cell line NS0-derived recombinant human Endoglin/CD105. Glu26-Gly586. Accession # Q5T9B9.
Usage
Application WB, FC, IHC, IF
Dilutions Western Blot (0.25 µg/mL); Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (5-15 µg/mL); Immunofluorescence (5-15 µg/mL)
Reactivity Human
Validation Knockout Validated.
Specificity Detects human Endoglin in direct ELISAs and Western Blots. In direct ELISAs, less than 15% cross-reactivity with recombinant mouse Endoglin and recombinant rat Endoglin is observed.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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