eIF4E siRNA II - CD BioSciences

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eIF4E siRNA II

eIF4E siRNA II

SPR-00430

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1 Unit Online Inquiry
Target Information
Target Name eIF4E
Gene Abbr. EIF4E
Gene ID 1977
Full Name eukaryotic translation initiation factor 4E
Alias AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F
Introduction Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure to mediate the initiation of translation. eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex. eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 phosphorylates eIF4E at Ser209 in vivo. Two Erk and p38 MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for Mnk1 kinase activity. The carboxy-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148, and Ser1192. Phosphorylation at these sites is blocked by the PI3 kinase inhibitor LY294002 and by the FRAP/mTOR inhibitor rapamycin.
Usage
Application RNA interference
Reactivity
Storage & Handling
Storage Buffer The siRNA product is supplied in RNAse-free water.
Storage Temp. Aliquot and store at -20 °C.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.