DUSP6/MKP3 Antibody - CD BioSciences

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DUSP6/MKP3 Antibody

DUSP6/MKP3 Antibody

SPA-03142

Size Price
100 µg Online Inquiry
25 µg Online Inquiry
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Target Information
Target Name DUSP6/MKP3
Gene Abbr. DUSP6
Gene ID 1848
Full Name dual specificity phosphatase 6
Alias HH19, MKP3, PYST1
Introduction MAP kinases are inactivated by dual-specificity protein phosphatases (DUSPs) that differ in their substrate specificity, tissue distribution, inducibility by extracellular stimuli, and cellular localization. DUSPs, also known as MAPK phosphatases (MKP), specifically dephosphorylate both threonine and tyrosine residues in MAPK P-loops and have been shown to play important roles in regulating the function of the MAPK family. At least 13 members of the family (DUSP1-10, DUSP14, DUSP16, and DUSP22) display unique substrate specificities for various MAP kinases. MAPK phosphatases typically contain an amino-terminal rhodanese-fold responsible for DUSP docking to MAPK family members and a carboxy-terminal catalytic domain. These phosphatases can play important roles in development, immune system function, stress responses, and metabolic homeostasis. In addition, research studies have implicated DUSPs in the development of cancer and the response of cancer cells to chemotherapy.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 363209
Isotype IgG2A
Immunogen E. coli-derived recombinant human MKP-3. Met1-Thr381. Q16828.
Usage
Application IF
Dilutions Immunofluorescence (8-25 µg/mL)
MW(KDa) 42
Reactivity Human
Specificity Detects human MKP-3 in direct ELISAs.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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