DEPTOR/DEPDC6 Antibody - CD BioSciences

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DEPTOR/DEPDC6 Antibody

DEPTOR/DEPDC6 Antibody

SPA-02896

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25 µg Online Inquiry
100 µg Online Inquiry
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Target Information
Target Name DEPTOR/DEPDC6
Gene Abbr. DEPTOR
Gene ID 64798
Full Name DEP domain containing MTOR interacting protein
Alias DEP.6, DEPDC6
Introduction DEPTOR/DEPDC6 is a component of both mTORC1 and mTORC2 complexes. It interacts with mTOR and inhibits mTORC1 and mTORC2 kinase activities. mTOR, along with casein kinase I, phosphorylates DEPTOR/DEPDC6 in the presence of growth signals, which leads to the degradation of DEPTOR/DEPDC6. Research studies have shown that transgenic mice overexpressing DEPTOR/DEPDC6 have more white adipose tissue, and DEPTOR/DEPDC6 expression levels increase in the white adipose tissue of obese humans. Furthermore, the expression of DEPTOR/DEPDC6 is induced during mouse adipocyte differentiation. Together these findings suggest that DEPTOR/DEPDC6 regulates adipogenesis.
Product Details
Host Sheep
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen E. coli-derived recombinant human DEPTOR/DEPDC6. Ala31-Gly158. Q8TB45.
Usage
Application WB, IHC
Dilutions Western Blot (1 µg/mL); Immunohistochemistry (5-15 µg/mL)
MW(KDa) 48
Reactivity Human
Specificity Detects recombinant human DEPTOR/DEPDC6 in direct ELISAs and Western Blots.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.