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DDR2 Antibody
SPA-02870
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DDR2 |
| Gene Abbr. | DDR2 |
| Gene ID | 4921 |
| Full Name | discoidin domain receptor tyrosine kinase 2 |
| Alias | MIG20a, NTRKR3, TKT, TYRO10, WRCN |
| Introduction | The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling. Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion.Injection of colon tumor cells into DDR2 knock out mice predisposes the hepatic stellate cells to colon tumor metastasis. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human DDR2. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1:1000-1:10000); Immunohistochemistry (1:100-1:1000) |
| MW(KDa) | 120-140 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS, 20% Glycerol (pH 7). |
| Preservative | 0.025% Proclin 300 |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.