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DCLK3 Antibody
SPA-02839
| Size | Price |
| 0.1 mg | Online Inquiry |
| 0.025 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DCLK3 |
| Gene Abbr. | DCLK3 |
| Gene ID | 85443 |
| Full Name | doublecortin like kinase 3 |
| Alias | CLR, DCAMKL3, DCDC3C, DCK3 |
| Introduction | DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A 14 amino acid synthetic peptide near the amino terminus of human DCLK3. The immunogen is located within the last 50 amino acids of DCLK3. Amino Acid Squence: SEGHFRSQHKRVVE. |
| Usage | |
|---|---|
| Application | WB, ELISA, IHC, IF |
| Dilutions | Western Blot (1-2 µg/mL); ELISA (1:100-1:2000); Immunohistochemistry (5 µg/mL); Immunofluorescence (20 µg/mL) |
| Reactivity | Human, Mouse |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.