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DC-SIGNR/CD299/CLEC4M (Chimeric) Antibody
SPA-02838
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.2 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DC-SIGNR/CD299 |
| Gene Abbr. | CLEC4M |
| Gene ID | 10332 |
| Full Name | C-type lectin domain family 4 member M |
| Alias | CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR |
| Introduction | This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 16E7 |
| Isotype | IgG Kappa |
| Immunogen | CD299. |
| Usage | |
|---|---|
| Application | WB, FC, IF, IHC |
| Dilutions | Flow Cytometry (1:10-1:1000); Immunohistochemistry (1:10-1:500) |
| Reactivity | Human |
| Specificity | Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Proclin 300 |
| Storage Temp. | Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.