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CUL4A siRNA
SPR-01432
| Size | Price |
| 1 Unit | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CUL4A |
| Gene Abbr. | CUL4A |
| Gene ID | 8451 |
| Full Name | cullin 4A |
| Introduction | Cullin-4 (CUL4) is a member of the cullin family of related ubiquitin ligases. A pair of mammalian CUL4 proteins - CUL4A and CUL4B - has been identified. The carboxy-terminal domain of CUL4 interacts with Rbx1 and E2 enzyme while the amino-terminal CUL4 domain interacts with BPB domain of UV-damaged DNA binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex. This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment. The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression, transcription, and development. |
| Usage | |
|---|---|
| Application | RNA interference |
| Reactivity | |
| Storage & Handling | |
|---|---|
| Storage Buffer | The siRNA product is supplied in RNAse-free water. |
| Storage Temp. | Aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.