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CUL4A Antibody
SPA-02451
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CUL4A |
| Gene Abbr. | CUL4A |
| Gene ID | 8451 |
| Full Name | cullin 4A |
| Introduction | Cullin-4 (CUL4) is a member of the cullin family of related ubiquitin ligases. A pair of mammalian CUL4 proteins - CUL4A and CUL4B - has been identified. The carboxy-terminal domain of CUL4 interacts with Rbx1 and E2 enzyme while the amino-terminal CUL4 domain interacts with BPB domain of UV-damaged DNA binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex. This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment. The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression, transcription, and development. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Immunogen | Synthetic peptide corresponding residues surrounding Ser12 of human CUL4A. |
| Source/Purification | Antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Ser12 of human CUL4A. Antibodies are purified by peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:50) |
| MW(KDa) | 80, 82 |
| Reactivity | Human, Monkey |
| Sensitivity | Endogenous |
| Specificity | Detects endogenous levels of total human CUL4A protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.