Crk Antibody - CD BioSciences

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Crk Antibody

Crk Antibody

SPA-02375

Size Price
0.1 mL Online Inquiry
0.025 mL Online Inquiry
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Target Information
Target Name Crk
Gene Abbr. CRK
Gene ID 1398
Full Name CRK proto-oncogene, adaptor protein
Alias CRKII, p38
Introduction CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 463414
Isotype IgG2B
Immunogen E. coli-derived recombinant human Crk. Gln205-Ser304. P46108.
Usage
Application WB
Dilutions Western Blot (1 µg/mL)
MW(KDa) 42
Reactivity Human, Mouse
Specificity Detects human Crk in direct ELISAs and human and mouse Crk in Western Blots.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.