CREB Antibody - CD BioSciences

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CREB Antibody

CREB Antibody

SPA-02340

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
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Target Information
Target Name CREB
Gene Abbr. CREB1
Gene ID 1385
Full Name cAMP responsive element binding protein 1
Alias CREB, CREB-1
Introduction CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2.
Product Details
Host Goat
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen E. coli-derived recombinant human CREB. Lys136-Asp341. P16220.
Usage
Application WB, IHC, ChIP, IF
Dilutions Western Blot (0.5 µg/mL); Immunohistochemistry (5-15 µg/mL); Chromatin Immunoprecipitation (5 µg/5x10^6 cells); Immunofluorescence (5-15 µg/mL)
MW(KDa) 43
Reactivity Human
Specificity Detects human CREB in Western Blots.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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