CREB Antibody - CD BioSciences

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CREB Antibody

CREB Antibody

SPA-02337

Size Price
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100 µg Online Inquiry
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Target Information
Target Name CREB
Gene Abbr. CREB1
Gene ID 1385
Full Name cAMP responsive element binding protein 1
Alias CREB, CREB-1
Introduction CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 82B514.2
Isotype IgG1
Immunogen A portion of amino acids 100-150 of human CREB was used as the immunogen.
Usage
Application WB
Dilutions Western Blot (2-4 µg/mL)
MW(KDa) 43
Reactivity Human
Specificity In HeLa, a 43 kDa band is observed.
Storage & Handling
Storage Buffer PBS containing 0.2% gelatin.
Preservative 0.05% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

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