cPLA2 Antibody - CD BioSciences

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cPLA2 Antibody

cPLA2 Antibody

SPA-02321

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100 µg Online Inquiry
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Target Information
Target Name cPLA2
Gene Abbr. PLA2G4A
Gene ID 5321
Full Name phospholipase A2 group IVA
Alias GURDP, PLA2G4, cPLA2, cPLA2-alpha
Introduction Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid. cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity. Calcium binding to the amino-terminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane. Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at Ser505 and Ser727 stimulates its catalytic activity.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D11H4
Immunogen Synthetic peptide corresponding to residues surrounding Ala452 of human cPLA2 protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala452 of human cPLA2 protein.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 98
Reactivity Human
Sensitivity Endogenous
Specificity It detects endogenous levels of total cPLA2 protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.