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CNP/NPPC Antibody
SPA-02278
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CNP/NPPC |
| Gene Abbr. | NPPC |
| Gene ID | 4880 |
| Full Name | natriuretic peptide C |
| Alias | CNP, CNP2 |
| Introduction | C-Type Natriuretic Peptide (CNP) belongs to the natriuretic peptide family and functions in an autocrine or paracrine fashion. CNP interacts with the GC-B/NPR-B receptor to promote vasorelaxation, vascular remodeling, and the growth and differentiation of bone and neural tissue. CNP is synthesized as a prohormone that is cleaved intracellularly by furin, yielding a 49 aa propeptide and a 53 aa mature peptide (CNP53). Additional cleavage of the mature peptide generates 29 aa and 22 aa peptides (CNP29 and CNP22) which have comparable activity in some assays. Within the 53 aa mature CNP, human shares 96% aa sequence identity with mouse and rat. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | 347608 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant human CNP. Lys24-Cys126. P23582. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1 µg/mL) |
| Reactivity | Human |
| Specificity | Detects the Pro form of human CNP (amino acids 24-126) in direct ELISAs and Western Blots. Does not detect the CNP29 peptide (amino acids 98‑126). In direct ELISAs and Western Blots, no cross-reactivity with recombinant human (rh) ANP precursor or rhBNP precursor is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.