CK1 Antibody - CD BioSciences

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CK1 Antibody

CK1 Antibody

SPA-02263

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100 µg Online Inquiry
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Target Information
Target Name CK1
Gene Abbr. CSNK1A1
Gene ID 1452
Full Name casein kinase 1 alpha 1
Alias CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1
Introduction Casein Kinase I (CK1 or CKI) is the name given to a family of kinases consisting of multiple isoforms (α, α', β, γ1-3, δ, and ε) with a conserved N-terminal kinase domain and a variable C-terminal sequence that determines subcellular localization and regulates enzyme activity. Indeed, multiple inhibitory autophosphorylation sites have been identified near the C terminus of CK1ε. This ubiquitously expressed family of protein kinases has been implicated in multiple processes including DNA repair, cell morphology, and Wnt signaling. Perhaps the best understood role of CK1 is to provide the priming phosphorylation of β-catenin at Ser45 to produce the consensus GSK-3 substrate motif (S/T-X-X-X-pS).
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to amino acid residues near the middle of human casein kinase I-alpha 1.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acid residues near the middle of human casein kinase I-alpha 1. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 34
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity This antibody detects endogenous levels of total casein kinase I-alpha 1 protein. This antibody may cross-react with casein kinase I-epsilon, casein kinase I-delta, and casein kinase I-gamma.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.