CD4 Antibody - CD BioSciences

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CD4 Antibody

CD4 Antibody

SPA-01983

Size Price
0.025 mL Online Inquiry
0.1 mL Online Inquiry
More Options Online Inquiry
Target Information
Target Name CD4
Gene Abbr. CD4
Gene ID 920
Full Name CD4 molecule
Alias CD4mut
Introduction Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. RM345
Isotype IgG
Immunogen A peptide corresponding to the N-terminus of human CD4.
Usage
Application WB, IHC
Dilutions Western Blot (1:100-1:2000); Immunohistochemistry (1:10-1:500)
Reactivity Human
Specificity This antibody reacts to the extracellular domain of human CD4.
Storage & Handling
Storage Buffer 50% Glycerol/PBS with 1% BSA.
Preservative 0.09% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.