CCR7 Antibody - CD BioSciences

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CCR7 Antibody

CCR7 Antibody

SPA-01783

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name CCR7
Gene Abbr. CCR7
Gene ID 1236
Full Name C-C motif chemokine receptor 7
Alias BLR2, CC-CKR-7, CCR-7, CD197, CDw197
Introduction CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.
Product Details
Host Rat
Clonality Monoclonal
Clone No. 4B12
Isotype IgG2A
Immunogen RBC-2H3 cells expressing mouse CCR7. NP_031745.
Usage
Application FC, IF
Dilutions Flow Cytometry (0.25 µg/10^6 cells); Immunofluorescence (8-25 µg/mL); Neutralization (2-10 µg/mL)
Reactivity Mouse
Specificity Detects mouse CCR7.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.