CCR7 Antibody - CD BioSciences

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CCR7 Antibody

CCR7 Antibody

SPA-01774

Size Price
0.02 mg Online Inquiry
0.1 mg Online Inquiry
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Target Information
Target Name CCR7
Gene Abbr. CCR7
Gene ID 1236
Full Name C-C motif chemokine receptor 7
Alias BLR2, CC-CKR-7, CCR-7, CD197, CDw197
Introduction CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.
Product Details
Host Goat
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Synthetic peptide: DPGKPRKNVLVVALLVIFQVC, corresponding to amino acids 2-22 of Mouse CCR7.
Usage
Application WB, ELISA, FC, IF, IHC
Dilutions Western Blot (1:1000); ELISA (1:100000); Flow Cytometry (1:10); Immunofluorescence (1:10-1:500); Immunohistochemistry (1:10-1:500)
Reactivity Human, Mouse, Rat
Specificity Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region.
Storage & Handling
Storage Buffer 10 mM KHPO4, 0.14 M NaCl and 1.0 mg/mL BSA.
Preservative 0.1% Sodium Azide
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.