CCR2 Antibody - CD BioSciences

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CCR2 Antibody

CCR2 Antibody

SPA-01744

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100 µg Online Inquiry
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Target Information
Target Name CCR2
Gene Abbr. CCR2
Gene ID 729230
Full Name C-C motif chemokine receptor 2
Alias CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192
Introduction CCR2, or C-C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.
Product Details
Host Rat
Clonality Monoclonal
Clone No. 475301
Isotype IgG2B
Immunogen L1.2 mouse pro-B cell line transfected with mouse CCR2.
Usage
Application FC
Dilutions Flow Cytometry (0.25 μg/10^6 cells)
Reactivity Mouse
Specificity Detects mouse CCR2 transfectants but not the parental cell line in flow
cytometry. Does not detect HEK293 human embryonic kidney cell line
transfected with mouse CCR5 in flow cytometry.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.