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CCR2 Antibody
SPA-01742
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CCR2 |
| Gene Abbr. | CCR2 |
| Gene ID | 729230 |
| Full Name | C-C motif chemokine receptor 2 |
| Alias | CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192 |
| Introduction | CCR2, or C-C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 48607 |
| Isotype | IgG2B |
| Immunogen | NS0 mouse myeloma cell line transfected with human CCR2. Met1-Leu360. Accession # NP_001116868. |
| Usage | |
|---|---|
| Application | FC, IHC |
| Dilutions | Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (8-25 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human CCR-2 transfectants but not the parental cell line or CCR-5 transfectants. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.