Caspase-8 Antibody - CD BioSciences

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Caspase-8 Antibody

Caspase-8 Antibody

SPA-01438

Size Price
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100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Rat
Clonality Monoclonal
Clone No. 3B10
Isotype IgG1 Kappa
Immunogen Recombinant mouse Caspase-8 (p20 subunit).
Usage
Application WB, ELISA, FC, IF, IHC
MW(KDa) 18, 43, 57
Reactivity Mouse
Specificity Recognizes the p20 subunit of mouse Caspase-8. Detects bands of ~55kDa (full-length Caspase-8) and ~18kDa (apoptosis-induced cleavage fragment) by Western Blot. Does not cross-react with human Caspase-8.
Storage & Handling
Storage Buffer PBS.
Preservative 0.02% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.