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Caspase-8 Antibody
SPA-01435
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Caspase-8 |
| Gene Abbr. | CASP8 |
| Gene ID | 841 |
| Full Name | caspase 8 |
| Alias | ALPS2B, CAP4, Casp-8, FLICE, MACH |
| Introduction | Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Recombinant full length human Caspase 8 protein. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Immunohistochemistry (1:50-1:100) |
| MW(KDa) | 18, 43, 57 |
| Reactivity | Human, Mouse, Rat, Bovine, Primate |
| Specificity | This reacts with a 55 kDa protein. Caspase 8 has an N-terminal domain with sequence homology to the death effector domain (DED) of FADD. Caspase 8 binds to DED of FADD. Caspase 8 is activated by association with Fas/FADD death-inducing signaling complex to release two active subunits, p18 and p10 into the cytosol, where they activate other caspases amplifying the apoptotic signal. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS with BSA. |
| Preservative | Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.