Caspase-8 Antibody - CD BioSciences


Caspase-8 Antibody

Caspase-8 Antibody


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Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D35G2
Immunogen Synthetic peptide corresponding to residues near the carboxyl terminus of human caspase-8 protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human caspase-8 protein.
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 18, 43, 57
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity It detects endogenous levels of total caspase-8, including the p10 subunit of the activated protein. Caspase-8 Rabbit mAb may also cross-react with overexpressed levels of caspase-10.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.