CaMKII-α Antibody - CD BioSciences

service-banner

CaMKII-α Antibody

CaMKII-α Antibody

SPA-01323

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name CaMKII
Gene Abbr. CAMK2A
Gene ID 815
Full Name calcium/calmodulin dependent protein kinase II alpha
Alias CAMKA, CaMKIINalpha, CaMKIIalpha, MRD53, MRT63
Introduction CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T cell receptor signaling. CaMKII has catalytic and regulatory domains. Ca2+/calmodulin binding to the CaMKII regulatory domain relieves autoinhibition and activates the kinase. The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286. PKA (protein kinase A) prevents phospho-CaMKII (Thr286) dephosphorylation through an inhibitory effect on PP1.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D10C11
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of human CaMKII-α protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CaMKII-α protein.
Usage
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 50
Reactivity Human, Mouse, Rat
Sensitivity Endogenous
Specificity It recognizes endogenous levels of total CaMKII-α protein. The peptide sequence used as the antigen is not conserved in CaMKII-β, -γ, and -δ.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.