c-Myc Antibody - CD BioSciences

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c-Myc Antibody

c-Myc Antibody

SPA-01240

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100 µg Online Inquiry
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Target Information
Target Name c-Myc
Gene Abbr. MYC
Gene ID 4609
Full Name MYC proto-oncogene, bHLH transcription factor
Alias MRTL, MYCC, bHLHe39, c-Myc
Introduction Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis. These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription. Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families. The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior. The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription.
Product Details
Host Goat
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Goats were immunized with a synthetic peptide representing amino acid residues 410-419 (EQKLISEEDL) of human c-Myc conjugated to KLH. Antibody was isolated by affinity chromatography using the peptide immobilized on solid support.
Usage
Application WB, ELISA, IF, IHC, IP
Dilutions Western Blot (1:1000-1:30000); ELISA Coating (1:100-1:500); Primary (1:1000-1:30000); Immunofluorescence (1:100-1:400); Immunoprecipitation (1-4 μg/mg lysate)
MW(KDa) 62
Reactivity All Species Expected
Storage & Handling
Storage Buffer PBS.
Preservative 0.09% Sodium Azide
Storage Temp. Store at 4 °C.
Handling Do not freeze.

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