c-Abl Antibody - CD BioSciences

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c-Abl Antibody

c-Abl Antibody

SPA-01165

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100 µg Online Inquiry
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Target Information
Target Name c-Abl
Gene Abbr. ABL1
Gene ID 25
Full Name ABL proto-oncogene 1, non-receptor tyrosine kinase
Alias ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl
Introduction The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously expressed and highly conserved in metazoan evolution. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. It is implicated in regulating cell proliferation, differentiation, apoptosis, cell adhesion, and stress responses. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including integrin activation; PDGF stimulation; and binding to c-Jun, Nck, and RFX1. The in vivo mechanism for regulation of c-Abl kinase activity is not completely understood. Tyr245 is located in the linker region between the SH2 and catalytic domains. This positioning is conserved among Abl family members. Phosphorylation at Tyr245 is involved in the activation of c-Abl kinase. In addition, phosphorylation at Tyr412, which is located in the kinase activation loop of c-Abl, is required for kinase activity.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human c-Abl.
Usage
Application WB, IF, IHC
Dilutions Western Blot (1:500-1:3000); Immunofluorescence (1:100-1:1000); Immunohistochemistry (1:100-1:1000)
MW(KDa) 135 (c-Abl), 210 (Bcr-Abl)
Reactivity Human
Storage & Handling
Storage Buffer PBS (pH 7), 20% Glycerol, 1% BSA.
Preservative 0.01% Thimerosal
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

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