BMP-7 Antibody - CD BioSciences

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BMP-7 Antibody

BMP-7 Antibody

SPA-01103

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Target Information
Target Name BMP-7
Gene Abbr. BMP7
Gene ID 655
Full Name bone morphogenetic protein 7
Alias OP-1
Introduction Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation. BMPs belong to the TGF-β superfamily, playing many diverse functions during development. BMPs are synthesized as precursor proteins and then processed by cleavage to release the C-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5, and 8), resulting in the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems.BMP7, also known as osteogenic protein-1 (OP-1), is found to be upregulated in some cancer cells, and may play a role in cancer metastasis.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 164311
Isotype IgG2B
Immunogen Chinese hamster ovary cell line CHO-derived recombinant human BMP‑7. Ser293-His431. Accession # P18075.
Usage
Application WB, IHC
Dilutions Western Blot (1 µg/mL); Immunohistochemistry (8-25 µg/mL); Neutralization (1.5-6.0 µg/mL)
Reactivity Human
Specificity Detects human BMP-7 in direct ELISAs and Western Blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant human (rh) BMP-6 is observed and no cross-reactivity with rhBMP-2, -3, -4, -5, or -8 is observed.
Storage & Handling
Storage Buffer Supplied as a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C, as supplied. 1 month, 2 to 8 °C under sterile conditions after opening. 6 months, -20 to -70 °C under sterile conditions after opening.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.