BMP-6 Sandwich ELISA Kit - CD BioSciences

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BMP-6 Sandwich ELISA Kit

BMP-6 Sandwich ELISA Kit

SPK-00120

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5 X 96T Online Inquiry
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Target Information
Target Name BMP-6
Gene Abbr. Bmp6
Gene ID 12161
Full Name bone morphogenetic protein 6
Alias D13Wsu115, D13Wsu115e, Vg, Vgr1
Introduction Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation. BMPs belong to the TGF-β superfamily, playing many diverse functions during development. BMPs are synthesized as precursor proteins and then processed by cleavage to release the C-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5, and 8), resulting in the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems.BMP6 plays a critical role in iron metabolism, ovulation, and aldosterone production. Recent studies have shown that hypermethylation of the BMP6 gene promoter decreases its expression in several cancer types, which contributes to tumor growth and progression.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Assay Principle quantitative
Sensitivity 7.81 pg/mL
Detection Range 31.25 pg/mL - 2000 pg/mL
Sample Volume 50-100μL
Assay Time 1-5h
Detection Wavelength 450 nm
Precision Intra-assay Precision (Precision within an assay): CV%<8%.
Inter-assay Precision (Precision between assays): CV%<10%.
Storage & Handling
Storage Temp. Store at 2-8°C. Please refer to protocol.

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