Bcl2a1a cDNA ORF Clone, Mouse, In cloning vector - CD BioSciences

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Bcl2a1a cDNA ORF Clone, Mouse, In cloning vector

Bcl2a1a cDNA ORF Clone, Mouse, In cloning vector

SPD-00260

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Description
Full length Clone DNA of Mouse B-cell leukemia/lymphoma 2 related protein A1a.
Target Information
Species Mouse
Target Name A1/Bfl-1
Gene Abbr. Bcl2a1a
Gene ID 12044
Full Name B cell leukemia/lymphoma 2 related protein A1a
Alias A, A1, BB218357, Bcl2, Bcl2a1
Introduction The Bcl-2-related protein A1 (Bfl-1, BCL2A1) is an anti-apoptotic member of the Bcl-2 family originally cloned from mouse bone marrow as a granulocyte macrophage-colony stimulating factor (GM-CSF)-inducible gene. Expression of A1/Bfl-1 is primarily restricted to hematopoietic cells, although it has been detected in some non-hematopoietic tissues including lung and in endothelial cells. A1/Bfl-1 protein is rapidly induced by NF-κB and is elevated in response to a variety of factors that stimulate this pathway, including TNF-α and IL-1β, CD40, phorbol ester, and LPS. As with other Bcl-2 family proteins, A1/Bfl-1 functions by binding and antagonizing pro-apoptotic members of the family (Bid, Bim), which inhibits release of mitochondrial cytochrome c. In contrast, research studies indicate that the enzyme calpain cleaves A1/Bfl-1 at specific sites within the amino terminal region, creating pro-apoptotic, carboxy-terminal fragments that promote mitochondrial release of cytochrome c and apoptosis. Studies suggest a possible therapeutic strategy of targeting apoptosis through use of the specific A1/Bfl-1 cleavage fragments.
Product Details
Description Full length Clone DNA of Mouse B-cell leukemia/lymphoma 2 related protein A1a.
NCBI Ref Seq NM_009742.3
RefSeq ORF Size 519 bp
Sequence Information Identical with the Gene Bank Ref. ID sequence.
Vector pMD18-T Simple Vector
Quality Control The plasmid is confirmed by full-length sequencing.
Storage The lyophilized plasmid can be stored at ambient temperature for three months.
Usage
Sequencing Primers M13-47 and RV-M
Antibiotic in E.coli Ampicillin
Shipping Each tube contains lyophilized plasmid.
Storage The lyophilized plasmid can be stored at ambient temperature for three months.

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