Bcl-2 Sandwich ELISA Kit - CD BioSciences

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Bcl-2 Sandwich ELISA Kit

Bcl-2 Sandwich ELISA Kit

SPK-00094

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5 X 96T Online Inquiry
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Target Information
Target Name Bcl-2
Gene Abbr. Bcl2
Gene ID 12043
Full Name B cell leukemia/lymphoma 2
Alias AW986256, Bcl-, Bcl-2, C430015F12Rik, D630044D05Rik
Introduction Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release. It has been implicated in modulating mitochondrial calcium homeostasis and proton flux. Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, and Ser87. It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes. Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Assay Principle quantitative
Sensitivity 3.9 pg/mL
Detection Range 15.6 pg/mL - 1000 pg/mL
Sample Volume 50-100μL
Assay Time 1-5h
Detection Wavelength 450 nm
Precision Intra-assay Precision (Precision within an assay): CV%<8%.
Storage & Handling
Storage Temp. Store at 2-8°C. Please refer to protocol.

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