Bcl-2 Antibody - CD BioSciences

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Bcl-2 Antibody

Bcl-2 Antibody

SPA-00965

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Target Information
Target Name Bcl-2
Gene Abbr. BCL2
Gene ID 596
Full Name BCL2 apoptosis regulator
Alias Bcl-2, PPP1R50
Introduction Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release. It has been implicated in modulating mitochondrial calcium homeostasis and proton flux. Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, and Ser87. It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes. Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 118701
Isotype IgG1
Immunogen E. coli-derived recombinant human Bcl-2 minus the carboxyl-terminal mitochondrial targeting sequence. Met1-Asp211. P10415.
Usage
Application WB
Dilutions Western Blot (0.1-0.5 µg/mL)
MW(KDa) 26
Reactivity Human
Specificity Detects human Bcl-2 in Western Blots.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.