Bcl-10 Antibody - CD BioSciences

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Bcl-10 Antibody

Bcl-10 Antibody

SPA-00922

Size Price
0.1 mL Online Inquiry
0.025 mL Online Inquiry
More Options Online Inquiry
Target Information
Target Name Bcl-10
Gene Abbr. BCL10
Gene ID 8915
Full Name BCL10 immune signaling adaptor
Alias CARMEN, CIPER, CLAP, IMD37, c-E10
Introduction Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-κB. The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-κB activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1;14)(p22;q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-κB by T- and B-cell receptors. One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-κB activiation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-κB activation and cellular proliferation and also provides a negative feedback regulation of the NF-κB signaling to T cell signaling.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 4F8
Isotype IgG1
Immunogen Purified recombinant fragment of human BCL-10 expressed in E. coli.
Usage
Application WB, ELISA, FC, IF, IHC
Dilutions Western Blot (1:500-1:2000); ELISA (1:10000); Flow Cytometry (1:200-1:400); Immunofluorescence (1:200-1:1000); Immunohistochemistry (1:10-1:500)
MW(KDa) 28
Reactivity Human, Mouse
Storage & Handling
Storage Buffer PBS.
Preservative 0.03% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.