BAFF/BLyS/TNFSF13B Antibody - CD BioSciences

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BAFF/BLyS/TNFSF13B Antibody

BAFF/BLyS/TNFSF13B Antibody

SPA-00848

Size Price
0.05 mg Online Inquiry
More Options Online Inquiry
Target Information
Target Name BAFF
Gene Abbr. TNFSF13B
Gene ID 10673
Full Name TNF superfamily member 13b
Alias BAFF, BLYS, CD257, DTL, TALL-1
Introduction Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1, THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase, BAFF (for B cell activating factor belonging to the TNF family) and BLyS (B lymphocyte stimulator). Membrane-bound BLyS (BAFF) is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS (BAFF) acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. BLyS (BAFF) regulation is upregulated by interferon gamma. Overexpression of BLyS (BAFF) in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune -like symptoms, such as high levels of rheumatoid factors, anti-DNA autoantibodies, etc.. Two receptors for BLyS (BAFF) have been identified and termed as BCMA and TACI.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen A peptide corresponding to 16 amino acids near the carboxy terminus of human BAFF/BLyS/TNFSF13B. The immunogen is located within the last 50 amino acids of BAFF/BLyS/TNFSF13B. Amino Acid Sequence: EEGDELQLAIPRENAQ.
Usage
Application WB, ELISA, IF, IHC
Dilutions Western Blot (0.25-1 µg/mL); ELISA (1:100-1:2000); Immunofluorescence (1-20 µg/mL)
Reactivity Human, Mouse, Rat
Specificity Human BAFF/BLyS/TNFSF13B has 3 isoforms, including isoform 1 (285aa, 31kD), isoform 2 (266aa, 29kD) and isoform 3 (164aa, 17.6kD). Mouse BAFF/BLyS/TNFSF13B has 2 isoforms, including isoform 1 (309aa, 34kD) and isoform 2 (290aa, 32kD). Rat BAFF/BLyS/TNFSF13B has only one isoform (274aa, 30kD). This antibody can detect two longer human isoforms, mouse and rat.
Storage & Handling
Storage Buffer PBS.
Preservative 0.02% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.